Differential diagnosis of Herpes Zoster myelitis and ALS
Herpes virus myelitis (HVM) develops in 1.2 – 6.3% of cases as a complication of herpes infection with a herpes-zoster virus (Varicella zoster) [1, 2]. This complication mainly occurs in immunodeficiency patients (HIV-infected persons with other causes for immunodeficiency after long-time treatment with steroids, diabetes mellitus, etc.).
Specific phobia of amyotrophic lateral sclerosis (ALS phobia) – complex clinical and electromyographic analysis of 120 cases with elements of molecular genetic screening
We analyzed 120 cases of specific phobia of amyotrophic lateral sclerosis (ALS phobia), 38 males and 82 females within age range 16-48 years (average age 32±11 years).
A comparative study of the efficacy and safety of different pharmacological forms of cholinolytics and botulinum therapy at sialorrhea in patients with amyotrophic lateral sclerosis
Efficiency and safety of botulinum therapy (250U Dysport + Amitriptyline 25 mg/d and 500U Dysport) and different pharmacological forms of cholinolytics (Atropini sulfatis drops separately or with Ipratropium bromide (later Atrovent) solution for oral hygiene, Amitriptiline 25 mg/d separately or with Atrovent and Atropine, Scopoderm plaster and Buscopan 40 mg/d) were assessed in 70 patients with amyotrophic lateral sclerosis with bulbar impairment and consequential entry to different study groups.
118 ALS patients and 97 members of their families were examined. All patients and relatives were observed by psychiatrists. The assessment was carried out on the Hamilton Depression Scale (for patients and members of their families) and the scale of frontotemporal dementia (for patients).
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease with impairment of central and peripheral motoneurons, which, according to modern views, is not restricted by suffering related with the locomotor system disorder, but can be also accompanied by cognitive impairments designated as frontotemporal disfunction (FTD).
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease accompanied by impairment of central (CMN) and peripheral motoneurons (PMN), progressing course and inevitable development of terminal respiratory insufficiency (RI) (1). The main method of RI treatment at ALS is noninvasive lung ventilation (NLV).
The quality of rendering medical services to ALS patients in the RF and compliance has been analyzed in 251 ALS patients. 99 people have been examined at visit to the clinic, including the dynamic observation of 16 ALS patients, 152 patients have been consulted in absentia, including 28 ALS patients in dynamics. 79.8% of ALS patients are characterized with low compliance irrespective of the quality of help; 8.3% of patients are constantly observed at institutions or in private medical offices, where the International Standard for ALS Management is not observed. Only 11.9% of patients are constantly managed in the correspondence with the International Standard of medical services for ALS patients and are characterized with high compliance. The most effective system of help for ALS patients is a dualistic combined system integrating services proposed within the system of insurance medicine, private treatment institutions, charity organizations, structures of medical-social support with different levels of availability and ways of interaction between a customer and a representative of the juridical person rendering medical services.
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